Plica Syndrome — Genes & Biomarkers Gene / Biomarker Bad Score Free Actions Non-free Actions GENES BIOMARKERS MMP3 (rs679620) AA risk allele Rest, ice knee Physio + collagen supp. IL-6 (rs1800795) CC risk allele Anti-inflam. diet Omega-3 supplement TNF (rs1800629) AA risk allele Cold compress, rest NSAIDs / physio VEGF (rs2010963) CC risk allele Low-impact exercise Compression sleeve CRP >10 mg/L Rest, hydration NSAIDs, omega-3 IL-6 (serum) >7 pg/mL Anti-inflam. diet Curcumin supplement MMP-3 (serum) >10 ng/mL Avoid overuse Physiotherapy, brace Hyaluronic Acid <1.5 mg/mL Hydration, rest HA injection / supp.