Synovitis Genes and Biomarkers Table Synovitis — Genes & Biomarkers: Risk Thresholds and Management Biomarker / Gene Bad Score Free Actions Non-free Actions GENES BIOMARKERS TNF A allele (rs1800629) Omega-3, curcumin, exercise Anti-TNF biologics IL6 C allele (rs1800795) Green tea, anti-inflam. diet Tocilizumab (IL-6i) IL1B A allele (rs16944) Low-sugar diet, cold therapy Anakinra (IL-1 blocker) MMP3 5A/5A genotype Joint rest, low-impact exercise DMARDs, surgery eval CRP >10 mg/L Omega-3, weight loss, diet NSAIDs, corticosteroids ESR >30 mm/h Rest, hydration, plant diet Corticosteroids, DMARDs IL-6 >7 pg/mL Anti-inflam. diet, sleep opt. Tocilizumab, sarilumab RF >20 IU/mL Stress reduction, curcumin Methotrexate, rituximab