Tibial Fracture - Genes & Biomarkers Summary
Gene / Biomarker
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GENES
BIOMARKERS
COL1A1rs1107946 low-BMD alleleCalcium + Vit D-rich dietGenetic collagen panel
VDRReduced Vit D sensitivityDaily sunlight exposureVit D3 supplement
LRP5Loss-of-function variantWeight-bearing exerciseDEXA bone density scan
RUNX2Low osteoblast expressionResistance trainingOsteocalcin blood test
OPGLow OPG/RANKL ratioAvoid smoking & alcoholOPG/RANKL assay
Vitamin D<20 ng/mLSunlight + fatty fishVit D3 supplement
PTH>65 pg/mLCalcium-rich foodsPTH + calcium test
P1NP<20 ng/mLDaily walk + exerciseBone formation panel
CTX-1>0.57 ng/mLReduce alcohol, no smokingAnti-resorptive therapy
IGF-1<100 ng/mLProtein intake + sleepIGF-1 serum test
Magnesium<0.75 mmol/LNuts, seeds, leafy greensMg supplement (citrate)
hs-CRP>3 mg/LAnti-inflammatory dietInflammation panel test