Popliteal (back of knee) pain
Possible conditions
Semimembranosus Bursitis — 5 Genes And 7 Biomarkers To Track
Pain at the back of the knee that lingers, swells, and returns no matter what you try is a particular kind of frustrating. Semimembranosus bursitis — inflammation of the small fluid-filled sac nestled between the semimembranosus tendon and the medial gastrocnemius — is often underdiagnosed or lumped together with Baker's cyst and generic posterior knee pain.
Popliteal Tendinitis — 5 Genes And 7 Biomarkers To Track
Popliteal tendinitis does not get the same attention as Achilles tendinopathy or patellar tendinitis, but for anyone who has dealt with persistent lateral knee pain while running downhill, cycling, or changing direction repeatedly, it is every bit as frustrating.
Popliteus Tendon Tear Genes and Biomarkers: 6 Genes and 7 Biomarkers to Track
A popliteus tendon tear is one of those injuries that gets missed, misdiagnosed, or treated too generically. Located at the back of the knee, the popliteus muscle and its tendon play a quiet but critical role in stabilizing the joint during rotation and in unlocking the knee from full extension.
Posterior Knee Impingement Syndrome — 7 Biomarkers and 5 Genes to Track
There is a particular frustration in feeling pain at the back of your knee, especially when you cannot fully bend or extend without that deep, aching pinch. You may have been told to rest, apply ice, and do some generic stretching.
Fabella Syndrome — 7 Biomarkers and 5 Genes To Track
Persistent pain at the back of the knee that does not match any clean diagnosis is genuinely disorienting. Fabella syndrome is one of those conditions that falls through the cracks of standard orthopaedic workups — the fabella, a small sesamoid bone embedded in the lateral head of the gastrocnemius muscle, is present in roughly 10 to 40 percent of people and its prevalence has actually been…
PCL Mucoid Degeneration — 4 Genes and 6 Biomarkers to Track
Posterior cruciate ligament mucoid degeneration is one of those diagnoses that tends to arrive quietly — picked up on an MRI ordered for unexplained posterior knee pain, creeping stiffness, or a slow loss of full flexion.
Posterior Knee Capsule Tear — 5 Genes And 7 Biomarkers To Track
A posterior knee capsule tear places you in a particular kind of limbo. The injury is painful enough to stop daily activity, but the standard care pathway — rest, some ice, a physiotherapy referral, maybe an MRI — rarely explains why it happened or why recovery is slower for some people than others.
Popliteal Vein Thrombosis: 5 Genes And 6 Biomarkers To Track
A blood clot forming in the popliteal vein — the vessel running behind your knee — is not a random event. For most people who experience popliteal vein thrombosis, there is an underlying biological story that made it possible: a combination of inherited tendencies, acquired shifts in how the blood behaves, and environmental exposures that tipped the balance toward clotting.
Popliteal Adventitial Cyst Disease: 7 Biomarkers and 3 Genes to Track
If you're reading this, you've probably already heard the phrase "rare vascular condition of unknown cause" more than once, and it hasn't told you much. Popliteal adventitial cyst disease, also called cystic adventitial disease (CAD) of the popliteal artery, is one of those diagnoses that shows up on an MRI report with confidence but gets explained to the patient with a shrug.
Knee Myofascial Pain Syndrome: 4 Genes and 7 Biomarkers to Track
If you've been told your knee pain is "just tight muscles" or "just overuse," but the ache, the tender bands, and the referred pain up or down the leg keep coming back no matter how much you stretch, you already know that explanation doesn't hold up.
Knee Accessory Ossicle Syndrome: 4 Genes And 7 Biomarkers To Track
If you've been told you have an accessory ossicle near your knee — a fabella, a bipartite patella, a cyamella, or one of the smaller sesamoid bones that occasionally show up on an X-ray — you've probably also noticed how thin the follow-up advice tends to be.
Semimembranosus Tendinopathy Genes and Biomarkers: 6 Genes and 6 Biomarkers to Track
Semimembranosus tendinopathy has a specific, frustrating pattern: deep posteromedial knee or proximal hamstring pain that flares with running, lunging, or prolonged sitting, and that seems to improve with rest only to return the moment training resumes.
Popliteus Tendinopathy: 4 Genes and 7 Biomarkers to Track
If you have been dealing with a nagging ache behind the outer or back part of your knee, especially after downhill running, deep squats, or sudden pivoting, you have probably already heard the standard advice: rest it, ice it, stretch the hamstrings, maybe try some eccentric loading.
Popliteus Muscle Strain: 6 Genes And 7 Biomarkers To Track
If you've been told you have a popliteus strain, you already know the frustrating part isn't the diagnosis — it's the vagueness of what comes after. Rest a few weeks. Ice it. Strengthen the quad.